Medication · Medication
DOACs
Direct oral anticoagulants — newer blood thinners that, unlike warfarin, need no routine INR monitoring.
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A medication reference built from the interaction graph. It is not prescribing information — the label and your prescriber are.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Caution with St. John's Wort: Enzyme induction lowers DOAC levels — a real clot risk; do not combine.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
St. John's WortCaution
Enzyme induction lowers DOAC levels — a real clot risk; do not combine.
The evidence in words
What it is
Direct oral anticoagulants — newer blood thinners that, unlike warfarin, need no routine INR monitoring.
How it works
They directly inhibit factor Xa or thrombin. They don't interact with vitamin K, but enzyme-inducing supplements can lower their levels.
What it's used for
Atrial fibrillation and venous thromboembolism.
Supplement & drug interactions
DOACs has 1 documented interaction mapped below and in the interactions graph. Not vitamin-K-sensitive, so greens are fine — but St John's Wort (enzyme induction) can drop DOAC levels and cause clots, and antiplatelet supplements still add bleeding risk. Clear supplements with the prescriber.
The rule
This is a medication reference for spotting interactions, not dosing advice. Every change to a supplement stack around a prescription belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Anticoagulants (Warfarin)Warfarin is a vitamin-K-antagonist anticoagulant with a narrow therapeutic window measured by INR.Evidence grade A
- AntiplateletsDrugs that reduce platelet clumping to prevent arterial clots.Evidence grade A
- ADHD StimulantsPrescription stimulants for attention-deficit/hyperactivity disorder.Evidence grade A
- Blood-Pressure MedicationsThe families of drugs that lower blood pressure — ACE inhibitors, ARBs, calcium-channel blockers, beta-blockers.Evidence grade A
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.