PrometheusGeneral

Rapamycin (Sirolimus) and Supplements for longevity

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Rapamycin (Sirolimus)

A prescription mTOR inhibitor that extends lifespan in animals like nothing else — and the most serious off-label longevity experiment in humans.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Goal guide

Supplements for longevity

13 compounds relevant to longevity, ranked by overall evidence grade.

Grade B13 graded outcomesrevised Jul 10, 2026

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Rapamycin (Sirolimus)

  • Lifespan (animals) Large effectEvidence grade A
  • Human longevity Unclear effectEvidence grade D

Graded only in Supplements for longevity

  • Rapamycin (Sirolimus) Unclear effectEvidence grade B
  • NMN Unclear effectEvidence grade C
  • Nicotinamide Riboside Unclear effectEvidence grade C
  • Quercetin Unclear effectEvidence grade C
  • Spermidine Unclear effectEvidence grade C
  • Urolithin A Unclear effectEvidence grade C
  • Sulforaphane Unclear effectEvidence grade C
  • Ergothioneine Unclear effectEvidence grade C
  • Resveratrol Unclear effectEvidence grade D
  • Fisetin Unclear effectEvidence grade D
  • PQQ Unclear effectEvidence grade D
  • Calcium AKG Unclear effectEvidence grade D
  • Fo-Ti (He Shou Wu) Unclear effectEvidence grade D

What each entry says about the other

  • Supplements for longevity’s entry · Goes with: Grade B

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.