Magnesium and Magnesium + PPIs: one depletes the other
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Magnesium
A cofactor in 300+ reactions that a large fraction of adults under-consume — real, modest benefits for sleep, blood pressure, and migraine.
Grade B4 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Interaction
Magnesium + PPIs: one depletes the other
Prolonged PPI use can drive magnesium clinically low.
Grade B0 graded outcomesrevised Jul 10, 2026
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in Magnesium
- Correcting low status Moderate effectEvidence grade A
- Blood pressure Small effectEvidence grade B
- Migraine prophylaxis Moderate effectEvidence grade B
- Subjective sleep Small effectEvidence grade B
Graded only in Magnesium + PPIs: one depletes the other
None — every outcome it grades is graded in both.
Conditions
Only in Magnesium
- Migraine May improveEvidence grade B
- Hypertension May improveEvidence grade B
- Insomnia May improveEvidence grade C
Only in Magnesium + PPIs: one depletes the other
None.
What each entry says about the other
- Magnesium + PPIs: one depletes the other’s entry · Watch with: About Magnesium
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.