PrometheusGeneral

Creatine and Phosphatidic Acid

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Creatine

The most-studied performance supplement in existence — and it quietly helps brains too.

Grade A5 graded outcomesrevised Jun 20, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Phosphatidic Acid

An mTOR-signaling lipid with a couple of small muscle-growth studies — promising mechanism, thin evidence.

Grade C1 graded outcomerevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Creatine

  • Strength / power output Moderate effectEvidence grade A
  • Lean mass (with training) Moderate effectEvidence grade A
  • Working memory Small effectEvidence grade B
  • Sprint performance Small effectEvidence grade B
  • Bone density Unclear effectEvidence grade C

Graded only in Phosphatidic Acid

  • Lean mass / strength Small effectEvidence grade C

Conditions

Only in Creatine

Only in Phosphatidic Acid

None.

What each entry says about the other

  • Phosphatidic Acid’s entry · Works together: Complementary muscle-growth mechanisms.
  • Phosphatidic Acid’s entry · Goes with: Complementary muscle-growth mechanisms.

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.