Compound or practice · Supplement
7-Keto-DHEA
A non-hormonal DHEA metabolite pitched for metabolism with weak, industry-linked evidence.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Metabolic rate / weightEvidence grade D
Weak
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Metabolic rate / weight (grade D).
The evidence in words
What it is
7-keto-DHEA is a DHEA metabolite that doesn't convert to sex hormones, marketed for metabolic rate and weight.
How it works
Proposed to raise thermogenic enzyme activity without androgenic/estrogenic effects.
What the evidence shows
A few small, mostly manufacturer-linked studies suggested minor weight/metabolic effects; independent replication is lacking. Unconvincing.
Safety & interactions
Generally tolerated short-term; long-term data limited.
Bottom line
Non-hormonal, but the metabolism/weight claims aren't well supported. Low priority.
Related reading
Entries that share this one's tags or conditions.
- 7-Keto-DHEA for Metabolic rate / weightEvidence grade D — WeakEvidence grade D
- 7-Keto-DHEA: side effects, safety & interactionsGenerally tolerated short-term; long-term data limited.Evidence grade D
- Calcium AKGA metabolic intermediate with striking mouse-aging data and almost no human outcome evidence.Evidence grade D
- Calcium AKG for Biological aging (humans)Evidence grade D — One small studyEvidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.