Mild-to-moderate depression: what the evidence supports

2 graded interventions for mild-to-moderate depression, ranked by strength of evidence.

Overall grade: Grade B
Last revised: Jul 10, 2026; 2
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

2 at grade B — 2 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
St. John's WortCochrane: ~ as effective as SSRIs	Evidence grade B	Moderate	high
Saffron~30 mg/day	Evidence grade B	Moderate	mixed

St. John's WortEvidence grade B
Cochrane: ~ as effective as SSRIs
Moderatehigh
SaffronEvidence grade B
~30 mg/day
Moderatemixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Studies disagree: Saffron (mixed agreement).

The evidence in words

The evidence map

This is the ranked evidence for mild-to-moderate depression: every compound in the knowledge base with a graded effect, best-supported first. Grades reflect replication and effect size, not popularity or marketing.

Best-supported

St. John's Wort (grade B) — Cochrane: ~ as effective as SSRIs · Saffron (grade B) — ~30 mg/day

Weaker or unproven

Everything with a graded effect here clears at least grade B.

Goes with

St. John's WortGrade BEvidence grade B
SaffronGrade BEvidence grade B

Entries that share this one's tags or conditions.

Allergic rhinitis: what the evidence supports3 graded interventions for allergic rhinitis, ranked by strength of evidence.Evidence grade B
Antibiotic-associated diarrhea: what the evidence supports2 graded interventions for antibiotic-associated diarrhea, ranked by strength of evidence.Evidence grade B
Anxiety: what the evidence supports6 graded interventions for anxiety, ranked by strength of evidence.Evidence grade B
Benign prostatic hyperplasia: what the evidence supports3 graded interventions for benign prostatic hyperplasia, ranked by strength of evidence.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.