Cardiovascular events: what the evidence supports

4 graded interventions for cardiovascular events, ranked by strength of evidence.

Overall grade: Grade B
Last revised: Jul 10, 2026; 4
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade B · 1 at grade C · 2 at grade D — 4 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Red Yeast RiceOne large trial positive	Evidence grade B	Moderate	mixed
Plant Sterols / StanolsOutcome trials lacking	Evidence grade C	Unclear	low
Folate (B9)Homocysteine lowering did not cut events	Evidence grade D	Trivial	high
Niacin (B3)AIM-HIGH, HPS2-THRIVE null + harm	Evidence grade D	Trivial	high

Red Yeast RiceEvidence grade B
One large trial positive
Moderatemixed
Plant Sterols / StanolsEvidence grade C
Outcome trials lacking
Unclearlow
Folate (B9)Evidence grade D
Homocysteine lowering did not cut events
Trivialhigh
Niacin (B3)Evidence grade D
AIM-HIGH, HPS2-THRIVE null + harm
Trivialhigh

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Plant Sterols / Stanols (grade C); Folate (B9) (grade D); Niacin (B3) (grade D).
Studies disagree: Red Yeast Rice (mixed agreement).

The evidence in words

The evidence map

This is the ranked evidence for cardiovascular events: every compound in the knowledge base with a graded effect, best-supported first. Grades reflect replication and effect size, not popularity or marketing.

Best-supported

Red Yeast Rice (grade B) — One large trial positive

Weaker or unproven

Plant Sterols / Stanols (grade C) — Outcome trials lacking · Folate (B9) (grade D) — Homocysteine lowering did not cut events · Niacin (B3) (grade D) — AIM-HIGH, HPS2-THRIVE null + harm

Goes with

Red Yeast RiceGrade BEvidence grade B
Plant Sterols / StanolsGrade CEvidence grade A
Folate (B9)Grade DEvidence grade A
Niacin (B3)Grade DEvidence grade B

Entries that share this one's tags or conditions.

Allergic rhinitis: what the evidence supports3 graded interventions for allergic rhinitis, ranked by strength of evidence.Evidence grade B
Antibiotic-associated diarrhea: what the evidence supports2 graded interventions for antibiotic-associated diarrhea, ranked by strength of evidence.Evidence grade B
Anxiety: what the evidence supports6 graded interventions for anxiety, ranked by strength of evidence.Evidence grade B
Benign prostatic hyperplasia: what the evidence supports3 graded interventions for benign prostatic hyperplasia, ranked by strength of evidence.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.