Compound or practice · Supplement
Serrapeptase
A proteolytic enzyme sold for inflammation and pain with weak, low-quality human evidence.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Post-surgical swelling / painEvidence grade D
Low-quality
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Post-surgical swelling / pain (grade D).
The evidence in words
What it is
Serrapeptase is a proteolytic enzyme (originally from silkworm gut bacteria) marketed for inflammation, pain, and mucus.
How it works
It breaks down proteins and is proposed to reduce inflammation, edema, and mucus viscosity.
What the evidence shows
Older, mostly low-quality studies suggest reduced post-surgical swelling and ENT mucus; rigorous modern evidence is scarce and some regulators removed approvals. Plausible but poorly substantiated.
How to use it
Enteric-coated on an empty stomach if trialing.
Safety & interactions
Generally tolerated; theoretical bleeding and drug-absorption effects.
Bottom line
Popular for inflammation but thinly evidenced. Not a priority; bromelain has somewhat better support.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- If trialing
- Enteric-coated, empty stomach.
Related reading
Entries that share this one's tags or conditions.
- BromelainA pineapple enzyme with modest evidence for post-surgical swelling and sinusitis.Evidence grade C
- Serrapeptase for Post-surgical swelling / painEvidence grade D — Low-qualityEvidence grade D
- Serrapeptase: dosage and how to take itEnteric-coated, empty stomach.Evidence grade D
- Serrapeptase: side effects, safety & interactionsGenerally tolerated; theoretical bleeding and drug-absorption effects.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.