Compound or practice · Supplement
Pantethine
An active form of vitamin B5 that genuinely, if modestly, improves the lipid panel.
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Lipid panelEvidence grade B
LDL/TG down, HDL up
Smallhigh
The evidence in words
What it is
Pantethine is a derivative of pantothenic acid (B5) used to improve cholesterol and triglycerides.
How it works
As a precursor to coenzyme A, it modulates lipid synthesis, lowering LDL and triglycerides and raising HDL.
What the evidence shows
Multiple trials show pantethine (~600–900 mg/day) modestly lowers LDL and triglycerides and raises HDL over weeks — a real, if small, lipid effect with good tolerability. Not a statin replacement.
Safety & interactions
Well tolerated; mild GI effects.
Bottom line
A genuinely lipid-active B5 derivative for modest LDL/triglyceride improvement. Reasonable adjunct; not a statin.
Related reading
Entries that share this one's tags or conditions.
- Pantethine for Lipid panelEvidence grade B — LDL/TG down, HDL upEvidence grade B
- Pantethine: side effects, safety & interactionsWell tolerated; mild GI effects.Evidence grade B
- Artichoke Leaf ExtractA digestive-and-cholesterol botanical with modest LDL and dyspepsia data.Evidence grade C
- BerberineA plant alkaloid that behaves like a metabolic drug — real glucose and lipid effects, and it deserves drug-level caution.Evidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.