Compound or practice · Supplement
Noopept
A potent peptide-like nootropic popular online with almost no Western human trials.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- CognitionEvidence grade D
Limited Western data
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Cognition (grade D).
The evidence in words
What it is
Noopept is a synthetic peptide-derived compound, dosed in milligrams, marketed as a stronger racetam-like nootropic.
How it works
Proposed to raise BDNF/NGF and modulate glutamate; largely characterized in Russian and animal research.
What the evidence shows
Most evidence is Russian clinical and animal work in cognitive impairment; independent Western trials in healthy people are lacking. Unproven and legally grey.
Safety & interactions
Generally tolerated at low doses; long-term safety uncharacterized.
Bottom line
Heavily hyped online with thin independent evidence. Not established.
Related reading
Entries that share this one's tags or conditions.
- Noopept for CognitionEvidence grade D — Limited Western dataEvidence grade D
- Methylene BlueA century-old dye and drug repurposed as a low-dose mitochondrial nootropic — real pharmacology, serious MAOI-level interactions.Evidence grade C
- Noopept: side effects, safety & interactionsGenerally tolerated at low doses; long-term safety uncharacterized.Evidence grade D
- OxiracetamA stimulating racetam with sparse, dated human evidence.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.