PrometheusGeneral

Compound or practice · Supplement

Mulberry Leaf

A natural alpha-glucosidase inhibitor that genuinely flattens the post-meal glucose spike.

Overall grade
Grade C
Last revised
1
graded outcome
0
references listed
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A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

  • Post-meal glucoseEvidence grade C

    With carbs

    Moderatemixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

  • Thin evidence: Post-meal glucose (grade C).
  • Caution with Metformin: Additive glucose lowering.

Interactions

Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.

  • MetforminCaution

    Additive glucose lowering.

The evidence in words

What it is

Mulberry leaf extract contains DNJ (1-deoxynojirimycin), a natural carbohydrate-enzyme inhibitor.

How it works

DNJ inhibits intestinal alpha-glucosidase, slowing sugar absorption and blunting the post-meal glucose and insulin rise.

What the evidence shows

Multiple small trials show mulberry leaf reduces post-meal glucose and insulin spikes when taken with carbohydrate — a consistent, mechanistically clear effect. Longer-term HbA1c data are limited.

Safety & interactions

Generally safe; mild GI effects; additive with glucose-lowering drugs. metformin — Additive glucose lowering.

Bottom line

A legitimately-mechanistic post-meal glucose blunter. Take with carb-containing meals; watch for additive lows on diabetes meds.

Related reading

Entries that share this one's tags or conditions.

  • CinnamonA modest, inconsistent glucose helper — and a reminder that cassia cinnamon's coumarin can stress the liver at high doses.Evidence grade C
  • Alpha-Lipoic AcidAn antioxidant with genuine evidence for diabetic neuropathy symptoms and modest insulin-sensitivity effects.Evidence grade B
  • Apple Cider VinegarThe acetic acid modestly blunts post-meal glucose — small, real, and easy to overhype.Evidence grade C
  • Banaba (Corosolic Acid)A glucose-lowering leaf whose corosolic acid shows small post-meal effects in limited trials.Evidence grade C

Sources

This entry lists no references of its own.

Last revised . A grade is this entry's reading of the evidence, not medical advice.