Compound or practice · Supplement
Fadogia Agrestis
A trendy testosterone herb with essentially zero human data and animal toxicity signals — not worth the risk.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Testosterone (humans)Evidence grade D
No human trials
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Testosterone (humans) (grade D).
The evidence in words
What it is
Fadogia agrestis is a shrub popularized by podcasts for testosterone and libido, sold despite a near-total absence of human research.
How it works
Rodent studies suggest it may raise testosterone by stimulating luteinizing hormone signaling — unconfirmed in humans.
What the evidence shows
There are no meaningful human trials. Animal studies that reported testosterone increases also reported testicular toxicity at higher doses. Safety and efficacy in humans are simply unknown, which for a hormone-active compound is a reason for caution, not enthusiasm.
How to use it
Not recommended pending human safety and efficacy data.
Safety & interactions
Animal data show organ toxicity; human safety is uncharacterized.
Bottom line
Popular does not mean proven. With no human data and animal toxicity signals, this is one to skip until real research exists.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- n/a
- Not recommended.
Related reading
Entries that share this one's tags or conditions.
- Fadogia Agrestis for Testosterone (humans)Evidence grade D — No human trialsEvidence grade D
- Fadogia Agrestis: dosage and how to take itNot recommended.Evidence grade D
- Fadogia Agrestis: side effects, safety & interactionsAnimal data show organ toxicity; human safety is uncharacterized.Evidence grade D
- FenugreekA libido herb with reasonable sexual-function data and inconsistent testosterone claims — the effect people feel is desire, not androgens.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.