Evidence brief · Supplement
Vitamin E for All-cause mortality (high dose)
Evidence grade C — Meta-analysis suggests slight increase ≥400 IU
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- All-cause mortality (high dose)Evidence grade C
Meta-analysis suggests slight increase ≥400 IU
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: All-cause mortality (high dose) (grade C).
The evidence in words
The verdict
For all-cause mortality (high dose), Vitamin E earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Meta-analysis suggests slight increase ≥400 IU
How it might work
It sits in cell membranes and quenches lipid peroxidation, protecting polyunsaturated fats from oxidative chain reactions. The theory that this should prevent chronic disease drove decades of trials.
How to use it
Get it from nuts, seeds, and vegetable oils. Avoid routine high-dose (≥400 IU) supplements; niche therapeutic use belongs under medical supervision.
Safety & cautions
High doses thin the blood and raise bleeding risk, compounding anticoagulants and antiplatelets; meta-analyses link ≥400 IU/day to slightly higher mortality.
Bottom line
Skip the high-dose antioxidant capsules. Eat nuts and seeds. Reserve therapeutic doses for specific medical indications under care.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Food-first
- Nuts, seeds, oils; avoid routine ≥400 IU capsules.
Goes with
- Vitamin ERead the full Vitamin E monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Glutathione for Fatty liver markersEvidence grade C — ModestEvidence grade C
- Glutathione for Oxidative stress markersEvidence grade C — Raised storesEvidence grade C
- Milk Thistle (Silymarin) for Glycemic control (diabetes)Evidence grade C — ModestEvidence grade C
- Milk Thistle (Silymarin) for Liver enzymesEvidence grade C — Sometimes improvedEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.