Evidence brief · Supplement
Urolithin A for Mitochondrial markers
Evidence grade B — Gene-expression changes
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Mitochondrial markersEvidence grade B
Gene-expression changes
Moderatemixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Mitochondrial markers (mixed agreement).
The evidence in words
The verdict
For mitochondrial markers, Urolithin A earns evidence grade B (moderate effect, mixed consistency) — there is real evidence here. Gene-expression changes
How it might work
It induces mitophagy — the recycling of damaged mitochondria — improving mitochondrial quality in muscle.
How to use it
500–1,000 mg/day.
Safety & cautions
Well tolerated in trials.
Bottom line
A rare longevity ingredient with actual human muscle-function data, if modest. Reasonable to trial for mitochondrial/muscle support.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 500–1,000 mg/day.
Goes with
- Urolithin ARead the full Urolithin A monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Urolithin A for Muscle endurance (older adults)Evidence grade C — Early trialsEvidence grade C
- Nicotinamide Riboside for Blood NAD+Evidence grade A — Reliably raisedEvidence grade A
- Nicotinamide Riboside for Physical / metabolic functionEvidence grade C — InconsistentEvidence grade C
- NMN for Blood NAD+Evidence grade B — Reliably raisedEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.