Evidence brief · Supplement
Pantothenic Acid (B5) for Acne (high-dose B5)
Evidence grade D — Weak
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Acne (high-dose B5)Evidence grade D
Weak
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Acne (high-dose B5) (grade D).
The evidence in words
The verdict
For acne (high-dose b5), Pantothenic Acid (B5) earns evidence grade D (trivial effect, low consistency) — the evidence does not support the claim. Weak
How it might work
As coenzyme A it is essential to countless metabolic reactions; pantethine additionally influences cholesterol synthesis.
How to use it
No supplementation needed for adequacy; pantethine ~600–900 mg/day for lipids if used.
Safety & cautions
Very safe; GI upset at very high doses.
Bottom line
You already get enough B5. Pantethine is a minor lipid option; the acne megadosing is unconvincing.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Lipids (pantethine)
- 600–900 mg/day.
Goes with
- Pantothenic Acid (B5)Read the full Pantothenic Acid (B5) monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Pantothenic Acid (B5) for LDL/triglycerides (pantethine)Evidence grade C — ModestEvidence grade C
- Niacin (B3) for Cardiovascular eventsEvidence grade D — AIM-HIGH, HPS2-THRIVE null + harmEvidence grade D
- Niacin (B3) for HDL / triglyceridesEvidence grade A — Strong lipid-panel effectEvidence grade A
- Niacin (B3) for Non-melanoma skin cancer (nicotinamide)Evidence grade B — In high-risk patientsEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.