Evidence brief · Supplement
Lithium (Low-Dose) for Mood (supplement dose)
Evidence grade D — Minimal trial data
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Mood (supplement dose)Evidence grade D
Minimal trial data
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Mood (supplement dose) (grade D).
The evidence in words
The verdict
For mood (supplement dose), Lithium (Low-Dose) earns evidence grade D (unclear effect, low consistency) — the evidence does not support the claim. Minimal trial data
How it might work
Lithium modulates neurotrophic and signaling pathways (GSK-3, BDNF); at trace doses the clinical relevance is unclear.
How to use it
Not established; supplement doses are far below therapeutic lithium.
Safety & cautions
Low supplement doses appear low-risk, but lithium has a narrow therapeutic window at prescription levels and interacts with kidney/thyroid function and several drugs.
Bottom line
Interesting epidemiology, negligible trial evidence at supplement doses. Not a substitute for psychiatric care; the prescription drug is a separate, monitored medicine.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Not established
- Supplement doses far below therapeutic lithium.
Goes with
- Lithium (Low-Dose)Read the full Lithium (Low-Dose) monographEvidence grade D
Related reading
Entries that share this one's tags or conditions.
- Lithium (Low-Dose): dosage and how to take itSupplement doses far below therapeutic lithium.Evidence grade D
- Lithium (Low-Dose): side effects, safety & interactionsLow supplement doses appear low-risk, but lithium has a narrow therapeutic window at prescription levels and interacts wEvidence grade D
- Holy Basil (Tulsi) for Fasting glucoseEvidence grade C — ModestEvidence grade C
- Holy Basil (Tulsi) for Stress / anxietyEvidence grade C — Small studiesEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.