Compound or practice · Supplement
DMG (Dimethylglycine)
An old 'endurance and immune' supplement whose human performance claims never held up.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Endurance / immunityEvidence grade D
Unsupported
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Endurance / immunity (grade D).
The evidence in words
What it is
Dimethylglycine is a methyl-metabolism derivative once marketed (as 'B15') for endurance and immunity.
How it works
A methyl donor in one-carbon metabolism; proposed ergogenic mechanisms lack support.
What the evidence shows
Controlled studies found no meaningful effect on endurance or performance; immune claims are weak. A relic of dubious 'B15' marketing.
Safety & interactions
Generally safe.
Bottom line
No real evidence for performance or immunity. Skip it.
Related reading
Entries that share this one's tags or conditions.
- ATP (Peak ATP)Oral 'ATP' that doesn't reach muscle as ATP — small, mostly industry-linked performance signals.Evidence grade D
- Betaine (TMG)An osmolyte and methyl donor with modest power/body-composition data and reliable homocysteine lowering.Evidence grade C
- CordycepsA popular endurance mushroom whose human performance data are weak and inconsistent.Evidence grade D
- Deer Antler VelvetAn IGF-1 'anabolic' spray whose active hormone is destroyed by digestion — a long-running performance myth.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.