Vitamin D and Vitamin K2
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Vitamin D
A steroid hormone precursor that most temperate-latitude adults run low on — worth correcting, oversold as a cure-all.
Grade A5 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Compound or practice
Vitamin K2
The traffic cop for calcium — activates proteins that steer it into bone and away from arteries.
Grade B3 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in Vitamin D
- Correcting deficiency (25(OH)D) Large effectEvidence grade A
- Fracture / fall risk (deficient elderly + calcium) Moderate effectEvidence grade B
- Respiratory infection risk Small effectEvidence grade C
- Cancer / CVD prevention (replete adults) Trivial effectEvidence grade D
- Type 2 diabetes prevention Trivial effectEvidence grade D
Graded only in Vitamin K2
- Osteocalcin carboxylation Large effectEvidence grade A
- Arterial stiffness markers Small effectEvidence grade B
- Fracture reduction Unclear effectEvidence grade C
Conditions
Only in Vitamin D
- Osteoporosis / bone loss May improveEvidence grade B
- Seasonal low mood May improveEvidence grade C
- Autoimmune disease No clear effectEvidence grade C
Only in Vitamin K2
None.
What each entry says about the other
- Vitamin D’s entry · Works together: K2 directs the calcium D mobilizes into bone rather than soft tissue.
- Vitamin D’s entry · Goes with: K2 directs the calcium D mobilizes into bone rather than soft tissue.
- Vitamin K2’s entry · Works together: The canonical pairing — D mobilizes calcium, K2 directs it.
- Vitamin K2’s entry · Goes with: The canonical pairing — D mobilizes calcium, K2 directs it.
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.