PrometheusGeneral

Valerian and Melatonin

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Valerian

A traditional sedative herb with inconsistent trials and a common morning-grogginess complaint.

Grade C1 graded outcomerevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Melatonin

A circadian signal, not a sedative — brilliant for jet lag and shift work at low doses, mediocre as a nightly sleeping pill.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Valerian

  • Subjective sleep Small effectEvidence grade C

Graded only in Melatonin

  • Jet lag / circadian shift Moderate effectEvidence grade B
  • Sleep onset (insomnia) Small effectEvidence grade B

Conditions

Only in Valerian

None.

Only in Melatonin

What each entry says about the other

  • Valerian’s entry · Caution: Two sedating levers — pick one to avoid morning grog.
  • Valerian’s entry · Watch with: Two sedating levers — pick one to avoid morning grog.

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.