Soy Isoflavones and Black Cohosh
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Soy Isoflavones
Phytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.
Grade B2 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Compound or practice
Black Cohosh
A menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals.
Grade C1 graded outcomerevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
| Outcome | Soy Isoflavones | Black Cohosh |
|---|---|---|
| Menopausal hot flashes | Evidence grade BSmall effectmixedBetter in equol producers | Evidence grade CSmall effectmixedDivided trials |
Graded only in Soy Isoflavones
- Male testosterone Trivial effectEvidence grade D
Graded only in Black Cohosh
None — every outcome it grades is graded in both.
Conditions
- Menopause symptomsSoy Isoflavones: May improveEvidence grade BBlack Cohosh: May improveEvidence grade C
Only in Soy Isoflavones
None.
Only in Black Cohosh
None.
What each entry says about the other
Neither entry records anything about the other. That is not evidence that they do not interact — only that neither entry says.
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.