PrometheusGeneral

Sleep architecture and Magnesium L-Threonate

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Sleep architecture

The recovery system everything else compounds on — deep and REM timing matter more than raw hours.

Grade A4 graded outcomesrevised Jun 28, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Magnesium L-Threonate

The magnesium form built to cross the blood–brain barrier — promising for sleep quality, thin on hard outcomes.

Grade B4 graded outcomesrevised Jun 18, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Sleep architecture

  • Insomnia severity (CBT-I components) Large effectEvidence grade A
  • Deep-sleep minutes (schedule consistency) Moderate effectEvidence grade A
  • Next-day cognition Moderate effectEvidence grade A
  • REM cost of evening alcohol Moderate effectEvidence grade A

Graded only in Magnesium L-Threonate

  • Subjective sleep quality Moderate effectEvidence grade B
  • Deep sleep (wearable-measured) Small effectEvidence grade B
  • Working memory (older adults) Small effectEvidence grade B
  • Anxiety Unclear effectEvidence grade C

Conditions

  • InsomniaSleep architecture: ImprovesEvidence grade AMagnesium L-Threonate: ImprovesEvidence grade B

Only in Sleep architecture

Only in Magnesium L-Threonate

What each entry says about the other

  • Sleep architecture’s entry · Goes with: The supplement layer on top of the behavioral base
  • Magnesium L-Threonate’s entry · Goes with: The behavioral base this builds on — fix the schedule first

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.