PrometheusGeneral

Saffron and Saffron + SSRIs / SNRIs: use with caution

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Saffron

Surprisingly solid for low mood at ~30 mg/day — a rare botantical antidepressant with real trials, carrying the serotonergic caveat.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Interaction

Saffron + SSRIs / SNRIs: use with caution

Serotonergic — additive load; clear with prescriber.

Grade B0 graded outcomesrevised Jul 10, 2026

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Saffron

  • Mild-to-moderate depression Moderate effectEvidence grade B
  • Anxiety / PMS Small effectEvidence grade C

Graded only in Saffron + SSRIs / SNRIs: use with caution

None — every outcome it grades is graded in both.

Conditions

Only in Saffron

Only in Saffron + SSRIs / SNRIs: use with caution

None.

What each entry says about the other

  • Saffron + SSRIs / SNRIs: use with caution’s entry · Watch with: About Saffron

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.