PrometheusGeneral

Psyllium Husk and Berberine

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Psyllium Husk

The most boring A-grade on the shelf: a soluble fiber that improves regularity, LDL, and glucose — and binds your medications.

Grade A3 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Berberine

A plant alkaloid that behaves like a metabolic drug — real glucose and lipid effects, and it deserves drug-level caution.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Psyllium Husk

  • Constipation / regularity Moderate effectEvidence grade A
  • LDL cholesterol Small effectEvidence grade A
  • Post-meal glucose Small effectEvidence grade B

Graded only in Berberine

  • Fasting glucose / HbA1c Moderate effectEvidence grade B
  • LDL / triglycerides Small effectEvidence grade B

Conditions

Only in Psyllium Husk

Only in Berberine

What each entry says about the other

  • Psyllium Husk’s entry · Mind the timing: Slows berberine uptake — separate by 2 hours.
  • Psyllium Husk’s entry · Watch with: Slows berberine uptake — separate by 2 hours.
  • Berberine’s entry · Mind the timing: Fiber slows uptake — separate by 2 hours.
  • Berberine’s entry · Watch with: Fiber slows uptake — separate by 2 hours.

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.