PrometheusGeneral

Omega-3 (EPA/DHA) and Zone 2 training

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Omega-3 (EPA/DHA)

Triglyceride-lowering is bankable; everything else scales with your baseline fish intake.

Grade A4 graded outcomesrevised Jun 8, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Zone 2 training

The unglamorous aerobic base that moves resting HR, mitochondria, and long-term health risk more than anything else per hour.

Grade A4 graded outcomesrevised Jun 22, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Omega-3 (EPA/DHA)

  • Triglycerides Large effectEvidence grade A
  • Cardiovascular events (high-risk) Small effectEvidence grade B
  • Depression (adjunct, EPA-heavy) Small effectEvidence grade B
  • Joint soreness Small effectEvidence grade C

Graded only in Zone 2 training

  • Resting heart rate Moderate effectEvidence grade A
  • VO₂max (untrained→trained) Large effectEvidence grade A
  • Fat oxidation capacity Moderate effectEvidence grade A
  • All-cause mortality (cohort) Large effectEvidence grade B

Conditions

  • DepressionOmega-3 (EPA/DHA): May improveEvidence grade BZone 2 training: ImprovesEvidence grade B

Only in Omega-3 (EPA/DHA)

Only in Zone 2 training

What each entry says about the other

  • Omega-3 (EPA/DHA)’s entry · Goes with: The cardio-risk stack: base volume + lipid control
  • Zone 2 training’s entry · Goes with: The cardio-risk stack: base volume + lipid control

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.