Omega-3 (EPA/DHA) and Vitamin D
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Omega-3 (EPA/DHA)
Triglyceride-lowering is bankable; everything else scales with your baseline fish intake.
Grade A4 graded outcomesrevised Jun 8, 2026
A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.
Compound or practice
Vitamin D
A steroid hormone precursor that most temperate-latitude adults run low on — worth correcting, oversold as a cure-all.
Grade A5 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in Omega-3 (EPA/DHA)
- Triglycerides Large effectEvidence grade A
- Cardiovascular events (high-risk) Small effectEvidence grade B
- Depression (adjunct, EPA-heavy) Small effectEvidence grade B
- Joint soreness Small effectEvidence grade C
Graded only in Vitamin D
- Correcting deficiency (25(OH)D) Large effectEvidence grade A
- Fracture / fall risk (deficient elderly + calcium) Moderate effectEvidence grade B
- Respiratory infection risk Small effectEvidence grade C
- Cancer / CVD prevention (replete adults) Trivial effectEvidence grade D
- Type 2 diabetes prevention Trivial effectEvidence grade D
Conditions
Only in Omega-3 (EPA/DHA)
- Hypertriglyceridemia ImprovesEvidence grade A
- Depression May improveEvidence grade B
- Rheumatoid arthritis ImprovesEvidence grade B
- Atrial fibrillation May worsenEvidence grade B
Only in Vitamin D
- Osteoporosis / bone loss May improveEvidence grade B
- Seasonal low mood May improveEvidence grade C
- Autoimmune disease No clear effectEvidence grade C
What each entry says about the other
Neither entry records anything about the other. That is not evidence that they do not interact — only that neither entry says.
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.