N-Acetylcysteine (NAC) and Glutathione
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
N-Acetylcysteine (NAC)
A glutathione precursor with real mucolytic and psychiatric-adjunct evidence — and the antidote for acetaminophen overdose.
Grade B3 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Compound or practice
Glutathione
The master antioxidant — better raised by making it (NAC, glycine) than by swallowing it, though liposomal forms help.
Grade C2 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in N-Acetylcysteine (NAC)
- Glutathione / oxidative markers Moderate effectEvidence grade B
- OCD / trichotillomania (adjunct) Small effectEvidence grade B
- Mucus clearance Moderate effectEvidence grade A
Graded only in Glutathione
- Oxidative stress markers Small effectEvidence grade C
- Fatty liver markers Small effectEvidence grade C
What each entry says about the other
- Glutathione’s entry · Works together: NAC supplies cysteine, the rate-limiting glutathione precursor.
- Glutathione’s entry · Goes with: NAC supplies cysteine, the rate-limiting glutathione precursor.
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.