Melatonin and Melatonin for Jet lag / circadian shift
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Melatonin
A circadian signal, not a sedative — brilliant for jet lag and shift work at low doses, mediocre as a nightly sleeping pill.
Grade B2 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Evidence brief
Melatonin for Jet lag / circadian shift
Evidence grade B — Timing-dependent
Grade B1 graded outcomerevised Jul 10, 2026
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
| Outcome | Melatonin | Melatonin for Jet lag / circadian shift |
|---|---|---|
| Jet lag / circadian shift | Evidence grade BModerate effecthighTiming-dependent | Evidence grade BModerate effecthighTiming-dependent |
Graded only in Melatonin
- Sleep onset (insomnia) Small effectEvidence grade B
Graded only in Melatonin for Jet lag / circadian shift
None — every outcome it grades is graded in both.
Conditions
Only in Melatonin
- Jet lag ImprovesEvidence grade B
- Delayed sleep phase ImprovesEvidence grade B
Only in Melatonin for Jet lag / circadian shift
None.
What each entry says about the other
- Melatonin for Jet lag / circadian shift’s entry · Goes with: Read the full Melatonin monograph
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.