PrometheusGeneral

St. John's Wort + Statins: use with caution and St. John's Wort

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Interaction

St. John's Wort + Statins: use with caution

Induction can lower levels of CYP3A4-metabolized statins, blunting their effect.

Grade B0 graded outcomesrevised Jul 10, 2026

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

Compound or practice

St. John's Wort

Genuinely works for mild-to-moderate depression — and is the single most dangerous supplement for drug interactions.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in St. John's Wort + Statins: use with caution

None — every outcome it grades is graded in both.

Graded only in St. John's Wort

  • Mild-to-moderate depression Moderate effectEvidence grade B
  • Severe depression Unclear effectEvidence grade C

Conditions

Only in St. John's Wort + Statins: use with caution

None.

Only in St. John's Wort

What each entry says about the other

  • St. John's Wort + Statins: use with caution’s entry · Watch with: About St. John's Wort

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.