PrometheusGeneral

Supplements for mood and Acetyl-L-Carnitine (ALCAR)

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Goal guide

Supplements for mood

11 compounds relevant to mood, ranked by overall evidence grade.

Grade B11 graded outcomesrevised Jul 10, 2026

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

Compound or practice

Acetyl-L-Carnitine (ALCAR)

The brain-penetrant carnitine — real evidence for diabetic neuropathy, softer signals for mood and aging cognition.

Grade B3 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Supplements for mood

  • Curcumin (Turmeric) Unclear effectEvidence grade B
  • St. John's Wort Unclear effectEvidence grade B
  • Saffron Unclear effectEvidence grade B
  • SAM-e Unclear effectEvidence grade B
  • Acetyl-L-Carnitine (ALCAR) Unclear effectEvidence grade B
  • L-Tryptophan / 5-HTP Unclear effectEvidence grade C
  • Mucuna Pruriens (L-Dopa) Unclear effectEvidence grade C
  • Uridine Unclear effectEvidence grade C
  • Sarcosine Unclear effectEvidence grade C
  • Kanna (Sceletium tortuosum) Unclear effectEvidence grade C
  • Lithium (Low-Dose) Unclear effectEvidence grade D

Graded only in Acetyl-L-Carnitine (ALCAR)

  • Diabetic neuropathy pain Moderate effectEvidence grade B
  • Depression (older adults) Small effectEvidence grade B
  • Cognition (MCI/aging) Small effectEvidence grade C

What each entry says about the other

  • Supplements for mood’s entry · Goes with: Grade B

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.