Supplements for metabolic health and Berberine
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Goal guide
Supplements for metabolic health
47 compounds relevant to metabolic health, ranked by overall evidence grade.
Grade A47 graded outcomesrevised Jul 10, 2026
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
Compound or practice
Berberine
A plant alkaloid that behaves like a metabolic drug — real glucose and lipid effects, and it deserves drug-level caution.
Grade B2 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in Supplements for metabolic health
- Plant Sterols / Stanols Unclear effectEvidence grade A
- Garlic Unclear effectEvidence grade B
- Berberine Unclear effectEvidence grade B
- Coenzyme Q10 Unclear effectEvidence grade B
- Red Yeast Rice Unclear effectEvidence grade B
- Alpha-Lipoic Acid Unclear effectEvidence grade B
- Inositol (Myo-Inositol) Unclear effectEvidence grade B
- Cocoa Flavanols Unclear effectEvidence grade B
- Hibiscus Unclear effectEvidence grade B
- Horse Chestnut Unclear effectEvidence grade B
- Diosmin / Hesperidin Unclear effectEvidence grade B
- Green Tea Extract (EGCG) Unclear effectEvidence grade C
- MCT Oil Unclear effectEvidence grade C
- Cinnamon Unclear effectEvidence grade C
- NMN Unclear effectEvidence grade C
- Nicotinamide Riboside Unclear effectEvidence grade C
- Quercetin Unclear effectEvidence grade C
- Spermidine Unclear effectEvidence grade C
- Urolithin A Unclear effectEvidence grade C
- Sulforaphane Unclear effectEvidence grade C
- Hawthorn Unclear effectEvidence grade C
- Carnosine Unclear effectEvidence grade C
- Gymnema Sylvestre Unclear effectEvidence grade C
- Banaba (Corosolic Acid) Unclear effectEvidence grade C
- Bitter Melon Unclear effectEvidence grade C
- Bergamot (Citrus Bergamia) Unclear effectEvidence grade C
- Artichoke Leaf Extract Unclear effectEvidence grade C
- Olive Leaf Extract Unclear effectEvidence grade C
- Lycopene Unclear effectEvidence grade C
- Spirulina Unclear effectEvidence grade C
- American Ginseng Unclear effectEvidence grade C
- Pycnogenol (Pine Bark) Unclear effectEvidence grade C
- Grape Seed Extract Unclear effectEvidence grade C
- Apple Cider Vinegar Unclear effectEvidence grade C
- Chlorella Unclear effectEvidence grade C
- Nattokinase Unclear effectEvidence grade C
- Gynostemma (Jiaogulan) Unclear effectEvidence grade C
- Mulberry Leaf Unclear effectEvidence grade C
- Akkermansia muciniphila Unclear effectEvidence grade C
- Chromium Unclear effectEvidence grade D
- CLA (Conjugated Linoleic Acid) Unclear effectEvidence grade D
- Resveratrol Unclear effectEvidence grade D
- Fisetin Unclear effectEvidence grade D
- PQQ Unclear effectEvidence grade D
- Calcium AKG Unclear effectEvidence grade D
- Guggul Unclear effectEvidence grade D
- Policosanol Unclear effectEvidence grade D
Graded only in Berberine
- Fasting glucose / HbA1c Moderate effectEvidence grade B
- LDL / triglycerides Small effectEvidence grade B
Conditions
Only in Supplements for metabolic health
None.
Only in Berberine
- Type 2 diabetes / prediabetes May improveEvidence grade B
What each entry says about the other
- Supplements for metabolic health’s entry · Goes with: Grade B
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.