PrometheusGeneral

Glycine and Magnesium

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Glycine

A cheap amino acid that lowers core temperature for easier sleep onset and supports collagen and glutathione.

Grade B2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Magnesium

A cofactor in 300+ reactions that a large fraction of adults under-consume — real, modest benefits for sleep, blood pressure, and migraine.

Grade B4 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Glycine

  • Sleep onset / quality Small effectEvidence grade B
  • Next-day alertness Small effectEvidence grade C

Graded only in Magnesium

  • Correcting low status Moderate effectEvidence grade A
  • Blood pressure Small effectEvidence grade B
  • Migraine prophylaxis Moderate effectEvidence grade B
  • Subjective sleep Small effectEvidence grade B

Conditions

Only in Glycine

None.

Only in Magnesium

What each entry says about the other

  • Glycine’s entry · Works together: The evening onset-plus-architecture pairing.
  • Glycine’s entry · Goes with: The evening onset-plus-architecture pairing.
  • Magnesium’s entry · Works together: The evening sleep-onset pairing.
  • Magnesium’s entry · Goes with: The evening sleep-onset pairing.

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.