SAM-e for Osteoarthritis pain and SAM-e
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Evidence brief
SAM-e for Osteoarthritis pain
Evidence grade B — NSAID-comparable
Grade B1 graded outcomerevised Jul 10, 2026
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
Compound or practice
SAM-e
A methyl donor with genuine antidepressant and osteoarthritis evidence — effective, pricey, and serotonergic.
Grade B2 graded outcomesrevised Jul 10, 2026
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
| Outcome | SAM-e for Osteoarthritis pain | SAM-e |
|---|---|---|
| Osteoarthritis pain | Evidence grade BModerate effectmixedNSAID-comparable | Evidence grade BModerate effectmixedNSAID-comparable |
Graded only in SAM-e for Osteoarthritis pain
None — every outcome it grades is graded in both.
Graded only in SAM-e
- Depression Moderate effectEvidence grade B
What each entry says about the other
- SAM-e for Osteoarthritis pain’s entry · Goes with: Read the full SAM-e monograph
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.