PrometheusGeneral

Creatine and Betaine (TMG)

Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.

Compound or practice

Creatine

The most-studied performance supplement in existence — and it quietly helps brains too.

Grade A5 graded outcomesrevised Jun 20, 2026

A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.

Compound or practice

Betaine (TMG)

An osmolyte and methyl donor with modest power/body-composition data and reliable homocysteine lowering.

Grade C2 graded outcomesrevised Jul 10, 2026

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

Swap the two

Graded in both

Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.

No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.

Graded only in Creatine

  • Strength / power output Moderate effectEvidence grade A
  • Lean mass (with training) Moderate effectEvidence grade A
  • Working memory Small effectEvidence grade B
  • Sprint performance Small effectEvidence grade B
  • Bone density Unclear effectEvidence grade C

Graded only in Betaine (TMG)

  • Power / body composition Small effectEvidence grade C
  • Homocysteine Moderate effectEvidence grade B

Conditions

Only in Creatine

Only in Betaine (TMG)

None.

What each entry says about the other

  • Betaine (TMG)’s entry · Works together: Both support cellular hydration/creatine status.
  • Betaine (TMG)’s entry · Goes with: Both support cellular hydration/creatine status.

Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.