Caffeine + L-Theanine and Creatine
Each entry’s own grades, side by side. A grade says how strong the evidence is for one outcome — it does not rank one entry over the other.
Compound or practice
Caffeine + L-Theanine
The best-documented nootropic stack there is: coffee's focus without the jitter tax.
Grade B4 graded outcomesrevised Jun 12, 2026
A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.
Compound or practice
Creatine
The most-studied performance supplement in existence — and it quietly helps brains too.
Grade A5 graded outcomesrevised Jun 20, 2026
A hand-written entry in Prometheus's bundled library. Its grades are the entry's own reading of the evidence, not a peer-reviewed review.
Graded in both
Outcomes are matched by name. Two entries can describe the same outcome in different words, so one listed further down may still be graded in the other.
No outcome has the same name in both entries. They may still overlap under different wording — read the two lists below.
Graded only in Caffeine + L-Theanine
- Sustained attention Moderate effectEvidence grade B
- Reaction time Small effectEvidence grade A
- Jitter / anxiety reduction vs caffeine alone Moderate effectEvidence grade B
- Sleep harm from late dosing Large effectEvidence grade A
Graded only in Creatine
- Strength / power output Moderate effectEvidence grade A
- Lean mass (with training) Moderate effectEvidence grade A
- Working memory Small effectEvidence grade B
- Sprint performance Small effectEvidence grade B
- Bone density Unclear effectEvidence grade C
Conditions
Only in Caffeine + L-Theanine
- ADHD (adult) May improveEvidence grade C
- Anxiety disorders May worsenEvidence grade B
- Hypertension May worsenEvidence grade C
- Migraine May improveEvidence grade C
Only in Creatine
- Sarcopenia (age-related muscle loss) ImprovesEvidence grade B
- Depression May improveEvidence grade C
- Type 2 diabetes May improveEvidence grade C
- Chronic kidney disease No clear effectEvidence grade B
What each entry says about the other
- Creatine’s entry · Watch with: A thin, contradictory literature on caffeine blunting the ergogenic effect — likely fine at normal doses
Both columns are read from the entries as they stand in this library. A comparison is not advice to take either one, and it is no substitute for a clinician who knows the person.