Bovine Colostrum

First-milk immune factors with early evidence for gut barrier and reducing exercise/athlete infections.

Overall grade: Grade C
Last revised: Jul 10, 2026; 2
graded outcomes: 0
references listed

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

2 at grade C — 2 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Gut permeabilityReduced	Evidence grade C	Small	mixed
Athlete URTIsFewer infections	Evidence grade C	Small	mixed

Gut permeabilityEvidence grade C
Reduced
Smallmixed
Athlete URTIsEvidence grade C
Fewer infections
Smallmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Gut permeability (grade C); Athlete URTIs (grade C).

The evidence in words

What it is

Bovine colostrum is the antibody- and growth-factor-rich first milk, used for gut and immune support.

How it works

It supplies immunoglobulins, lactoferrin, and growth factors that support the gut lining and mucosal immunity.

What the evidence shows

Small trials suggest reduced gut permeability ('leaky gut'), fewer upper-respiratory infections in athletes, and reduced NSAID-induced gut damage. Promising and safe; evidence is early.

Safety & interactions

Generally safe; dairy-allergy caution.

Bottom line

An early-evidence gut-barrier and athlete-immunity supplement. Reasonable to trial; not yet firmly established.

Entries that share this one's tags or conditions.

Bovine Colostrum for Athlete URTIsEvidence grade C — Fewer infectionsEvidence grade C
Bovine Colostrum for Gut permeabilityEvidence grade C — ReducedEvidence grade C
Bovine Colostrum: side effects, safety & interactionsGenerally safe; dairy-allergy caution.Evidence grade C
LactoferrinAn iron-binding milk protein with real signals for gut immunity, iron status and acne — versatile, promising, still maturing.Evidence grade C

Sources

This entry lists no references of its own.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.