Compound or practice · Nutrition
Akkermansia muciniphila
A next-generation gut bacterium linked to metabolic health — one promising human trial, a lot still unknown.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Insulin sensitivity / metabolic markersEvidence grade C
One key trial
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Insulin sensitivity / metabolic markers (grade C).
The evidence in words
What it is
Akkermansia muciniphila is a mucin-degrading gut bacterium whose abundance correlates with leaner, more metabolically healthy people; now sold as a probiotic.
How it works
It strengthens the gut mucus barrier and signals to improve insulin sensitivity and reduce metabolic inflammation.
What the evidence shows
A landmark proof-of-concept trial found pasteurized Akkermansia improved insulin sensitivity and some metabolic markers in overweight adults — notably, the pasteurized form outperformed live. It's early: one main human trial, and long-term data are lacking.
Safety & interactions
Well tolerated in the trial; long-term safety of a novel single-strain probiotic is not established.
Bottom line
A genuinely exciting 'next-gen' probiotic with one supportive metabolic trial — worth watching, not yet a proven staple. The pasteurized form is the studied one.
Related reading
Entries that share this one's tags or conditions.
- Akkermansia muciniphila for Insulin sensitivity / metabolic markersEvidence grade C — One key trialEvidence grade C
- Akkermansia muciniphila: side effects, safety & interactionsWell tolerated in the trial; long-term safety of a novel single-strain probiotic is not established.Evidence grade C
- Saccharomyces BoulardiiA probiotic yeast with the best evidence for preventing antibiotic-associated and traveler's diarrhea.Evidence grade B
- Activated CharcoalA genuine poison-control adsorbent misused as a 'detox' and gas remedy — and it binds your medications.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.